How much should you expect to spend for a flight from Panama City to Mayaguez?

Flight prices from Panama City to Mayaguez change depending on demand and time of booking.

Pick a travel date to see today’s available fares.

Studies show that flying midweek — like on a Tuesday or Wednesday — can be cheaper than weekend flights. Still, airfares change frequently, so check updated prices on Jetcost.

Planning flights between Panama City and Mayaguez? Don’t forget the airport options

Especially when flying to medium or large cities, it's worth checking all possible airport combinations before booking.

• Airports in Panama City: 2 airports are listed in Panama City - Pacífico International Airport, Paitilla.
• Airports in Mayaguez: Only Mayaguez - Eugenio Maria de Hostos is currently available.

Check for differences in transport costs to and from each airport — they affect your total spend. Choosing the right airport can make a real difference in price and timing.

Find the best flight from Panama City to Mayaguez

With Jetcost, you can filter results by flight time, airline, price range, and layovers. Choose direct or connecting flights, round-trip or one-way, and compare offers from the best airlines and travel agencies.

Other popular destinations

Searching for flights to Puerto Rico? Travelers also looked at: Aguadilla, Culebra Airport, Mayaguez, Ponce, San Juan.

Use filters to exclude options that don’t match your budget or travel preferences and personalize your search for Panama City – Mayaguez flights.